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Acute Myeloid Leukemia
Research from A. Laurenzana and co-researchers yields new findings on acute myeloid leukemia
February 24th, 2009
According to recent research from Montreal, Canada, "Transcriptional silencing via promoter methylation of genes important for cell growth and differentiation plays a key role in myeloid leukemogenesis. We find that clinically achievable levels of 5-aza-2'-deoxycytidine (5-AZA-dC), a potent inhibitor of DNA methylation, can modify chromatin and restore the ability of tumor necrosis factor alpha (TNF alpha) to induce monocytic differentiation of the acute myeloid leukemia cells NB4 and U937." "Although 5-AZA-dC cannot fully induce differentiation, we show that 5-AZA-dC acts directly on TNF alpha-responsive promoters to facilitate TNF alpha-induced transcriptional...
Source: Cancer Weekly (2009-02-24)
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