Cancer Weekly
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Acute Promyelocytic Leukemia
Findings in acute promyelocytic leukemia reported from University of Montpellier
February 24th, 2009
"Micro(mi) RNAs are small noncoding RNAs that orchestrate many key aspects of cell physiology and their deregulation is often linked to distinct diseases including cancer. Here, we studied the contribution of miRNAs in a well-characterized human myeloid leukemia, acute promyelocytic leukemia (APL), targeted by retinoic acid and trioxide arsenic therapy," scientists writing in the journal Blood report. "We identified several miRNAs transcriptionally repressed by the APL-associated PML-RAR oncogene which are released after treatment with all-trans retinoic acid. These coregulated miRNAs were found to control, in a coordinated manner, crucial pathways linked to...
Source: Cancer Weekly (2009-02-24)
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