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Alzheimer Disease
University of Leeds details research in Alzheimer disease
February 24th, 2009
"Amyloid beta-peptide (A beta) accumulation leads to neurodegeneration and Alzheimer disease; however, amyloid metabolism is a dynamic process and enzymic mechanisms exist for A beta removal. Considerable controversy surrounds whether the intracellular domain of the amyloid precursor protein (AICD) regulates expression of the A beta-degrading metalloprotease, neprilysin (NEP)," scientists in Leeds, the United Kingdom report. "By comparing two neuroblastoma cell lines differing substantially in NEP expression, we show by chromatin immunoprecipitation (ChIP) that AICD is bound directly to the NEP promoter in high NEP-expresser (NB7) cells but not in low-expresser...
Source: Cancer Weekly (2009-02-24)
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