Cancer Weekly
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Angiogenesis
New angiogenesis research from United Arab Emirates University discussed
February 24th, 2009
"Salmonella enterica serovar Typhimurium (hereafter S. typhimurium) stains have been shown to exert a potent inhibitory effect on the growth of human and mouse tumors in experimental models. Our laboratory has previously demonstrated that an attenuated strain of S. typhimurium engineered to express IL2 (designated strain GIDIL2) has demonstrable immunopotentiating properties, particularly affecting the innate arm of the immune system," researchers in Al Ain, United Arab Emirates report. "In the present study, we wished to explore the properties of IL-2-expressing Salmonella as an oncotytic agent in the highly tumorigenic B16F1 melanoma mouse model and shed light on its...
Source: Cancer Weekly (2009-02-24)
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