Cancer Weekly
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Gene Therapy
Research data from M. Gimenezalejandre and colleagues update understanding of gene therapy
February 24th, 2009
According to a study from Barcelona, Spain, "A critical obstacle for efficient gene therapy and virotherapy of cancer with adenoviral vectors and oncolytic adenoviruses is to target tumor cells in vivo. Recent reports indicate that, contrary to the natural airborne infection of epithelial cells with adenovirus type 5 mediated by coxsackievirus B and adenovirus receptor (CAR) and integrins, blood-borne adenovirus infects hepatocytes mainly through an indirect pathway that involves blood coagulation factors." "In this report we have studied whether adenovirus also infects tumor cells in vivo by this pathway. In vitro and in vivo analyses show that vitamin K-dependent...
Source: Cancer Weekly (2009-02-24)
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