Cancer Weekly
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Cancer Gene Therapy
Research reports from University of California provide new insights into cancer gene therapy
March 3rd, 2009
According to a study from the United States, "Adoptive T-cell therapy is clinically efficacious in the treatment of select cancers. However, it is often difficult to obtain adequate numbers of tumor-specific T cells for therapy." "One method for overcoming this limitation is to generate tumor-specific T cells by retrovirally mediated T-cell-receptor (TCR) gene transfer. However, despite instances of therapeutic success, major obstacles remain, including attaining the survival of retrovirally modified T cells in vivo as well as inducing long-term and multi-gene retroviral expression. Using a murine model of adoptively transferred retrovirally modified CD8(+) T cells,...
Source: Cancer Weekly (2009-03-03)
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