Cancer Weekly
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Acute Lymphoblastic Leukemia
Findings from L. Kearney and co-authors broaden understanding of acute lymphoblastic leukemia
March 3rd, 2009
According to recent research from Sutton, the United Kingdom, "Children with Down syndrome (DS) have a greatly increased risk of acute megakaryoblastic leukemia (AMKL) and acute lymphoblastic leukemia (ALL). Both DS-AMKL and the related transient myeloproliferative disorder (TMD) have GATA1 mutations as obligatory, early events." "To identify mutations contributing to leukemogenesis in DS-ALL, we undertook sequencing of candidate genes, including FLT3, RAS, PTPN11, BRAF, and JAK2. Sequencing of the JAK2 pseudokinase domain identified a specific, acquired mutation, JAK2R683, in 12 (28%) of 42 DS-ALL cases. Functional studies of the common JAK2R683G mutation in murine...
Source: Cancer Weekly (2009-03-03)
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