Cancer Weekly
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Angiogenesis
Data on angiogenesis reported by researchers at University of British Columbia
March 3rd, 2009
According to recent research from Vancouver, Canada, "Nuclear factor kappa B (NF-kappa B) signaling is deregulated in many tumor types, resulting in aberrant expression and/or activation of NF-kappa B transcriptional complexes. We have previously reported that nuclear expression of the NF-kappa B subunit p50 is strongly correlated with melanoma progression and poor 5-year patient survival." "In this study, we used cDNA microarray to analyze the gene expression profiles of melanoma cells overexpressing NF-kappa B p50. We found that NF-kappa B p50 expression strongly induced interleukin-6 (IL-6) upregulation in melanoma cells at both the transcriptional and translational...
Source: Cancer Weekly (2009-03-03)
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