Cancer Weekly
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Angiogenesis
Research conducted at S. Sfar and co-researchers has updated our knowledge about angiogenesis
March 3rd, 2009
"The single-gene approaches in association studies of polygenic diseases are likely to provide limited value in predicting risk. The combined analysis of genetic variants that interact in the same pathway may amplify the effects of individual polymorphisms and enhance the predictive power," scientists in Monastir, Tunisia report. "To evaluate higher order gene-gene interaction, we have examined the contribution of four angiogenic gene polymorphisms (VEGF-1154G/A; VEGF634G/C; MMP9-1562C/T and TSP1-8831A/G) in combination to the risk of prostate cancer. For the combined analysis of VEGF and MMP9 SNPs, we found a significant gene-dosage effect for increasing numbers of...
Source: Cancer Weekly (2009-03-03)
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