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Cancer Gene Therapy
Data on cancer gene therapy discussed by researchers at Dankook University
March 3rd, 2009
"A trans-splicing ribozyme that can specifically reprogram human telomerase reverse transcriptase ( hTERT) RNA was previously suggested as a useful tool for tumor-targeted gene therapy. In this study, we applied transcriptional targeting with the RNA replacement approach to target liver cancer cells by combining a liver-selective promoter with an hTERT-mediated cancer-specific ribozyme," scientists in South Korea report. "To validate effects of this system in vivo, we constructed an adenovirus encoding for the hTERT-targeting trans-splicing ribozyme under the control of a liver-selective phosphoenolpyruvate carboxykinase promoter. We observed that intratumoral injection...
Source: Cancer Weekly (2009-03-03)
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