Cancer Weekly
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Angiogenesis
Researchers from University of Nebraska detail new studies and findings in the area of angiogenesis
March 3rd, 2009
According to recent research from the United States, "Crucial steps in tumor growth and metastasis are proliferation, survival, and neovascularization. Previously, we have shown that receptors for CXCL-8, CXCR1, and CXCR2 are expressed on endothelial cells and CXCR2 has been shown to be a putative receptor for angiogenic chemokines." "In this report, we examined whether tumor angiogenesis and growth of CXCL8-expressing human melanoma cells are regulated in vivo by a host CXCR2-dependent mechanism. We generated mCXCR2(-/-), mCXCR2(+/-), and wild-type nude mice following crosses between BALB/c mice heterozygous for nude(+/-) and heterozygous for mCXCR2(+/-). We observed a...
Source: Cancer Weekly (2009-03-03)
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