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Apoptosis
Data on apoptosis reported by M. Barbera and co-researchers
March 3rd, 2009
According to a study from Cambridge, the United Kingdom, "In order to proliferate, solid tumours require the development and continuous expansion of an organised host-derived vascular network. The anti-vascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA),emerged as derivative of the flavone-8-acetic acid (FAA) and xanthenone-4-acetic acid (XAA)." "Its anti-vascular activity is not based oil direct cytotoxic effects, but is characterized by an immune-mediated component, through the activation of NF-kappa B pathway, and a direct anti-vascular action, involving the induction of endothelial cell apoptosis and changes in tumour vessel permeability. Despite promising...
Source: Cancer Weekly (2009-03-03)
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