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Cancer Weekly

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Apoptosis



Research on apoptosis detailed by M. Tanaka and co-authors



March 3rd, 2009

"During the process of tumor progression and clinical treatments, tumor cells are exposed to oxidative stress. Tumor cells are frequently resistant to such stress by producing antiapoptotic signaling, including activation of Src family kinases (SFKs), although the molecular mechanism is not clear," scientists in Tsukiji, Japan report.

"In an attempt to identify the SFK-binding proteins selectively phosphorylated in gastric scirrhous carcinoma, we identified an uncharacterized protein, C9orf10. Here we report that C9orf10 ( designated Ossa for oxidative stress-associated Src activator) is a novel RNA-binding protein that guards cancer cells from oxidative stress-induced...


Source: Cancer Weekly (2009-03-03)

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