Cancer Weekly
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Cancer Gene Therapy
Findings from Washington University, Medical Department in cancer gene therapy reported
March 3rd, 2009
"The ability to achieve tumor selective expression of therapeutic genes is an area that needs improvement for cancer gene therapy to be successful. One approach to address this is through the use of promoters that can be controlled by external means, such as hyperthermia," researchers in the United States report. "In this regard, we constructed a replication-deficient adenovirus that consists of a mutated herpes simplex virus 1 thymidine kinase (mTK) fused to enhanced green fluorescent protein (EGFP) under the control of the full-length human heat shock (HS) 70b promoter. The virus (AdHSmTK-EGFP) was evaluated both in vitro and in vivo in oral squamous cell carcinoma...
Source: Cancer Weekly (2009-03-03)
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