Cancer Weekly
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Apoptosis
Study data from K. Hormicarver and colleagues update understanding of apoptosis
March 3rd, 2009
"Apoptosis is an important mechanism for maintaining tissue homeostasis and for preventing the proliferation of cells with mutations that could result in malignancy. Barrett's epithelium has been reported to be more resistant to apoptosis than normal esophageal squamous epithelium," scientists writing in the journal Cancer Research report. "We have explored the contribution of the nuclear factor-kappa B (NF-kappa B) pathway to apoptotic resistance in non-neoplastic, telomerase-immortalized esophageal squamous (NES) and Barrett's (BAR-T) epithelial cell lines. We exposed these cells to UV-B irradiation in doses known to cause DNA damage and to induce apoptosis in...
Source: Cancer Weekly (2009-03-03)
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