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Cancer Weekly

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Cancer Gene Therapy



New cancer gene therapy study findings have been published by scientists at Fourth Military Medical University



March 3rd, 2009

According to recent research from Xian, People's Republic of China, " Eukaryotic initiation factor eIF4E, an important regulator of translation, plays a crucial role in the malignant transformation, progression and chemoresistance of many human solid tumors. The overexpression of this gene has been found in a variety of human malignancies including breast carcinoma."

"In the present study, we attempted to explore the possibility of eIF4E as a therapeutic target for the treatment of human breast carcinoma using breast carcinoma cell line (MCF-7). Materials and methods The survivin promoter-driven eIF4E-shRNA vector was constructed on the basis of pSUPER.retro vector....


Source: Cancer Weekly (2009-03-03)

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