Johns Hopkins Medical Institutions

2 gene mutations linked to most common brain cancers -- and longer survival

Published in Cancer Weekly, March 3rd, 2009

Scientists at the Johns Hopkins Kimmel Cancer Center and Duke University Medical Center have linked mutations in two genes, IDH1 and IDH2, to nearly three-quarters of several of the most common types of brain cancers known as gliomas. Among the findings: people with certain tumors that carry these genetic alterations appear to survive at least twice as long as those without them.

Further research on the genes could also lead to more precise diagnosis and treatments, they said.

Reporting in the Feb. 19 issue of the New England Journal of Medicine, scientists say they looked for IDH1 and IDH2 gene alterations in material taken from 500 brain tumors and...

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Source: Cancer Weekly (2009-03-03)

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