Cancer Weekly
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Cancer Gene Therapy
New cancer gene therapy study findings have been reported by scientists at Gene Therapy Center
March 10th, 2009
According to recent research published in the journal BMC Cancer, "Chemoresistance is one of the main obstacles to successful cancer therapy and is frequently associated with Multidrug resistance (MDR). Many different mechanisms have been suggested to explain the development of an MDR phenotype in cancer cells." "One of the most studied mechanisms is the overexpression of P-glycoprotein (P-gp), which is a product of the MDR1 gene. Tumor cells often acquire the drug-resistance phenotype due to upregulation of the MDR1 gene. Overexpression of MDR1 gene has often been reported in primary gastric adenocarcinoma. This study investigated the role of p38-MAPK signal...
Source: Cancer Weekly (2009-03-10)
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