Cancer Weekly
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Cancer Gene Therapy
Research data from A. Mohr and colleagues update understanding of cancer gene therapy
March 10th, 2009
"Lung cancer is a major public health problem in the western world, and gene therapy strategies to tackle this disease systemically are often impaired by inefficient delivery of the vector to the tumour tissue. Some of the main factors inhibiting systemic delivery are found in the blood stream in the form of red and white blood cells (WBCs) and serum components," scientists in Galway, Ireland report. "Mesenchymal stem cells (MSCs) have been shown to home to tumour sites and could potentially act as a shield and vehicle for a tumouricidal gene therapy vector. Here, we describe the ability of an adenoviral vector expressing TRAIL (Ad.TR) to transduce MSCs and show the...
Source: Cancer Weekly (2009-03-10)
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