Cancer Weekly
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Cancer Vaccines
Studies conducted at J. Ruter et al on cancer vaccines recently published
March 10th, 2009
"Cancers express tumor associated antigens that should elicit immune attack, but spontaneous immune rejection of established cancer is rare. Recent data demonstrate that specific and active tumor-mediated mechanisms hinder host anti-tumor immunity," scientists writing in the journal Frontiers in Bioscience report. "CD4(+)CD25(+) T regulatory cells (Tregs) are important mediators of active immune evasion in cancer. Disrupting tumor-mediated mechanisms hindering host immunity is a novel approach to tumor immunotherapy. Treg depletion improves endogenous anti-tumor immunity and the efficacy of active immunotherapy in animal models for cancer, suggesting that...
Source: Cancer Weekly (2009-03-10)
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