Cancer Weekly
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Gene Therapy
Research from V.K. Agrawal and co-authors yields new data on gene therapy
March 10th, 2009
According to recent research from London, the United Kingdom, "Transfer of healthy autologous tissue as a microvascular free flap facilitates reconstruction during ablative cancer surgery. In addition to filling surgical defects, free flaps might concentrate viral vectors at the tumour bed and mediate local therapeutic effects." "We evaluated the magnitude, topography and duration of luciferase gene expression after plasmid and adenoviral delivery in rat superficial inferior epigastric (SIE) flaps. For plasmid delivery, luciferase expression was significantly increased by all transduction routes (topical, intraflap injection, intravascular) (P < 0.01) at day 1, but...
Source: Cancer Weekly (2009-03-10)
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