Cancer Weekly
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Gene Therapy
Study results from C. Barra and colleagues broaden understanding of gene therapy
March 10th, 2009
According to recent research from Ploufragan, France, "Adenovirus-based vectors are widely developed for potential utilization as vectors in vaccine and gene therapy strategies. We focused on developing a helper-dependent adenoviral (HD-Ad) vector for the potential use of CELO, a member of the Aviadenovirus genus, in avian species vaccination." "Our aim was to localize sequences which could play an essential role in CELO genome encapsidation and, when deleted, was unable to produce viruses to develop a helper CELO virus. A panel of 6 mutants with deletions between nt 80 and 350 of the CELO genome was constructed and characterized for its ability to produce viable virus....
Source: Cancer Weekly (2009-03-10)
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