Cancer Weekly
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Glioblastoma
Research on glioblastoma detailed by W.Q. Yu and co-authors
March 10th, 2009
"Despite advances in surgical technology and radiation therapy, the prognosis in the patients with malignant glioma remains poor. Recent studies show that interleukin-13 receptor {alpha}2 chain (IL-13Ra2), a brain tumor-associated receptor for IL-13, may play a role in immunotherapy for glioblastoma," scientists writing in the journal Cancer Immunology Immunotherapy report. "We thus amplified human IL-13Ra2 gene from the human glioblastoma cell line using RT-PCR and cloned the target gene into the pET-28a, a prokaryotic expressing plasmid. After transformation, the recombinant plasmid expressed a soluble protein induced by IPTG. The purified recombinant protein...
Source: Cancer Weekly (2009-03-10)
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