Lung Cancer

Findings in lung cancer reported from T. Oyama and co-researchers

Published in Cancer Weekly, March 10th, 2009

"Human aromatase (CYP19) responsible for the conversion of androgens to estrogens is expressed not only in gonads and adrenals but also in many other tissues, including normal lungs and lung cancers. To investigate the involvement of CYP19 in lung cancer development, purified CYP19 protein and antibody are required," scientists in Kitakyushu, Japan report.

"In this study, we have developed an efficient expression method of human aromatase in E. coli (> 1000 nmol/L culture). The protein purified from E. coli was used to raise an antibody against the human CYP19 in rabbits. The resulting antibody showed a high titer judged by ELISA, which allowed us to determine the...

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Source: Cancer Weekly (2009-03-10)

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