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Life Sciences
New data from M. Ni et al illuminate research in life sciences
March 10th, 2009
"We prepared single-chain immunoglobulin Fv fragments (scFv) SLH10 specific for the HepG2 cell line after biopanning from a large human-naive phage display library (Griffin. I Library). The three-dimensional (3D) structure of SLH10 was modelled by the Insight 11 molecule simulation software," scientists in Wuhan, People's Republic of China report. "The structure was refined using the molecular dynamics method. The structures with the least steric clashes and lowest energy were determined finally. The optimized structures of heavy (VH) and light (VL) variable chains of SLH10 scFv were obtained. Then SLH10 bivalent single-chain Fv (BsFv) was constructed that would be...
Source: Cancer Weekly (2009-03-10)
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