Cancer Weekly
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Cancer Gene Therapy
Investigators at University of Alberta release new data on cancer gene therapy
March 10th, 2009
A new study, 'Autotaxin protects MCF-7 breast cancer and MDA-MB-435 melanoma cells against Taxol-induced apoptosis,' is now available. According to recent research from Edmonton, Canada, "Autotaxin (ATX) promotes cancer cell survival, growth, migration, invasion and metastasis. ATX converts extracellular lysophosphatidylcholine (LPC) into lysophosphatidate (LPA)." "As these lipids have been reported to affect cell signaling through their own G-protein-coupled receptors, ATX could modify the balance of this signaling. Also, ATX affects cell adhesion independently of its catalytic activity. We investigated the interactions of ATX, LPC and LPA on the apoptotic effects of...
Source: Cancer Weekly (2009-03-10)
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