Cancer Weekly
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Chemotherapy
Investigators at Shandong University, Department of Hematology have published new data on chemotherapy
March 10th, 2009
A new study, 'Down-regulation of Notch-1 increases co-cultured Jurkat cell sensitivity to chemotherapy,' is now available. "The bone marrow (BM) microenvironment plays a critical role in malignant cell growth, patient survival and response to chemotherapy in hematologic malignancies. However, the molecular mechanisms of BM stromal cells (BMSCs)-mediated survival of tumor cell remain unclear," researchers in Jinan, People's Republic of China report. "In this study, to further evaluate the role of Notch-1 in vivo microenvironment, we investigated the influence of inhibiting Notch-1 pathway by Notch-1 siRNA on Jurkat cells in the co-culture system. We found that Notch-1...
Source: Cancer Weekly (2009-03-10)
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