Cancer Weekly
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Acute Leukemia
Recent findings in acute leukemia described by A.S. Drake and colleagues
March 10th, 2009
According to a study from the United States, "Acute leukemia with 11q23 aberrations is associated with a poor outcome with therapy. The lack of efficacy of conventional therapy has stimulated interest in developing novel strategies." "Recent studies have shown that 11q23-positive acute leukemia cells express the high molecular weight-melanoma associated antigen (HMW-MAA). This tumor antigen represents a useful target to control growth of human melanoma tumors in patients and in severe combined immunodeficient (SCID) mice, utilizing antibody-based immunotherapy. This effect appears to be mediated by inhibition of the HMW-MAA function such as triggering of the focal...
Source: Cancer Weekly (2009-03-10)
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