Cancer Weekly
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Apoptosis
Reports from Brown University add new data to research in apoptosis
March 10th, 2009
"Activation of the p53 tumor suppressor by cellular stress leads to variable responses ranging from growth inhibition to apoptosis. TIGAR is a novel p53-inducible gene that inhibits glycolysis by reducing cellular levels of fructose-2,6-bisphosphate, an activator of glycolysis and inhibitor of gluconeogenesis," scientists writing in the Journal of Biological Chemistry report. "Here we describe structural and biochemical studies of TIGAR from Danio rerio. The overall structure forms a histidine phosphatase fold with a phosphate molecule coordinated to the catalytic histidine residue and a second phosphate molecule in a position not observed in other phosphatases....
Source: Cancer Weekly (2009-03-10)
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