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Cancer Gene Therapy
Data on cancer gene therapy detailed by researchers at Case Western Reserve University, Department of Biochemistry
March 17th, 2009
A report, '9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-kappaB and p53 pathways,' is newly published data in Oncogene. According to a study from the United States, "Acquisition of a transformed phenotype involves deregulation of several signal transduction pathways contributing to unconstrained cell growth. Understanding the interplay of different cancer-related signaling pathways is important for development of efficacious multitargeted anticancer drugs." "The small molecule 9-aminoacridine (9AA) and its derivative, the antimalaria drug quinacrine, have selective toxicity for tumor cells and can simultaneously suppress nuclear...
Source: Cancer Weekly (2009-03-17)
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