Cancer Weekly
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Adenoma
Research on adenoma published by scientists at Mayo Clinic
March 17th, 2009
"Current stool DNA tests identify about half of individuals with colorectal cancers and miss most individuals with advanced adenomas. We developed a digital melt curve (DMC) assay to quantify low-abundance mutations in stool samples for detection of colorectal. neoplasms and compared this test with other approaches," investigators in the United States report. "We combined a melt curve assay with digital polymerase chain reaction and validated the quantitative range. We then evaluated its ability to detect neoplasms in 2 clinical studies. In study 1, stool samples from patients with colorectal tumors with known mutations (KRAS, APC, BRAF, TP53) were assayed. In study II,...
Source: Cancer Weekly (2009-03-17)
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