Cancer Weekly
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Angiogenesis
Reports from University of Regensburg describe recent advances in angiogenesis
March 17th, 2009
According to recent research published in the journal Hepatology, "Hepatocellular carcinoma (HCC) remains associated with a poor prognosis, but novel targeted therapies in combination with anti-angiogenic substances may offer new perspectives. We hypothesized that simultaneous targeting of tumor cells, endothelial cells, and pericytes would reduce growth and angiogenesis of HCC, which represents a highly vascularized tumor entity." "Recently, because of their anti-angiogenic properties, inhibitors of mammalian target of rapamycin (mTOR) have entered clinical trials for therapy of HCC. However, treatment with mTOR inhibitors may lead to paradoxical activation of...
Source: Cancer Weekly (2009-03-17)
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