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Cancer Gene Therapy
New cancer gene therapy data have been reported by scientists at University of Turku
March 24th, 2009
A new study, 'Suppression of breast cancer cell growth by a monoclonal antibody targeting cleavable ErbB4 isoforms,' is now available. According to recent research from Turku, Finland, "ErbB4 isoforms mediate different cellular activities depending on their susceptibility to proteolytic cleavage. The biological significance of ErbB4 cleavage in tumorigenesis, however, remains poorly understood." "Here, we describe characterization of a monoclonal antibody (mAb 1479) that selectively recognizes the ectodomain of cleavable ErbB4 JM-a isoforms both in vitro and in vivo. mAb 1479 was used to analyse ErbB4 JM-a expression and ectodomain shedding in a series of 17 matched...
Source: Cancer Weekly (2009-03-24)
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