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Cancer Gene Therapy
Scientists at Gunma University, Institute for Molecular and Cellular Regulation describe research in cancer gene therapy
March 24th, 2009
Research findings, 'LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites,' are discussed in a new report. "Malignant ascites from pancreatic cancer patients has been reported to stimulate migration of pancreatic cancer cells through lysophosphatidic acid (LPA) and LPA(1) receptors. Indeed, ascites-and LPA-induced migration was inhibited by Ki16425, an LPA(1) and LPA(3) antagonist, in Panc-1 cells," investigators in Maebashi, Japan report. "Unexpectedly, however, in the presence of Ki16425, ascites and LPA inhibited cell migration in response to...
Source: Cancer Weekly (2009-03-24)
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