Cancer Weekly
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Cancer Gene Therapy
Study data from A. Lopergolo and co-authors update knowledge of cancer gene therapy
March 24th, 2009
Data detailed in 'Apollon gene silencing induces apoptosis in breast cancer cells through p53 stabilisation and caspase-3 activation' have been presented. According to recent research from Milano, Italy, "We analysed the effects of small interfering RNA (siRNA)-mediated silencing of Apollon, a member of the inhibitors of apoptosis protein family, on the proliferative potential and ability of human breast cancer cell lines to undergo apoptosis. In wild-type p53 ZR75.1 cells, Apollon knockdown resulted in a marked, time-dependent decline of cell growth and an increased rate of apoptosis, which was associated with p53 stabilisation and activation of the mitochondrial-dependent apoptotic...
Source: Cancer Weekly (2009-03-24)
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