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Gene Therapy
Researchers from University of Sheffield discuss findings in gene therapy
March 24th, 2009
New investigation results, 'Bacterial delivery of a novel cytolysin to hypoxic areas of solid tumors,' are detailed in a study published in Gene Therapy. "The efficacy of current anti-cancer gene therapies is limited by the inability of gene vectors to penetrate the poorly vascularized, hypoxic regions of tumors, leaving these sites untreated. We describe a new approach for targeting gene therapy to these sites, which employs an attenuated strain of the non-pathogenic bacterium, Salmonella typhimurium, carrying an exogenous (that is, reporter or therapeutic) gene under the regulation of a new, highly hypoxia-inducible promoter (FF+20(*))," investigators in Sheffield, the...
Source: Cancer Weekly (2009-03-24)
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