Hepatocellular Cancer

Findings from Chongqing University advance knowledge in hepatocellular cancer

Published in Cancer Weekly, March 24th, 2009

According to recent research from Chongqing, People's Republic of China, "Hepatitis B virus (HBV) replicates in most tumor tissues of patients with HBV-associated hepatocellular carcinoma (HCC). In the present study, we have shown that the expression of HBV in the HCC cell lines, HepG2 and Huh7, down-regulated the expression of MHC class I-related molecule A (MICA), a ligand of the NKG2D receptor."

"Inhibition of HBV expression by small interference RNAs (siRNAs) in HepG2.2.15, a cell line that constitutively expresses HBV, induced up-regulation of MICA. The up-regulation of MICA increased the lysis of HepG2.2.15 cells by NK cells," wrote K.F. Tang and colleagues,...

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Source: Cancer Weekly (2009-03-24)

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