Cancer Weekly
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Angiogenesis
New findings from Z.F. Yi and co-authors in the area of angiogenesis published
March 24th, 2009
According to a study from Shanghai, People's Republic of China, "Many angiogenesis inhibitors are derived from large plasma proteins. Previous studies showed that the Kringle5-like domain (termed KV) in human apolipoprotein (a) is a potential antiangiogenic factor." "However, its active region and the underling molecular mechanism remain elusive. Here. we identified an 11-amino acid peptide (named KV11) H as the key region for the antiangiogenic function of the KV domain of apolipoprotein (a). We demonstrate that KV11 inhibits angiogenesis in vitro by suppressing human umbilical vein endothelial cell migration and microtubule formation. KV11 inhibits angiogenesis in...
Source: Cancer Weekly (2009-03-24)
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