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Angiogenesis
Studies from Stanford University further understanding of angiogenesis
March 24th, 2009
"Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) signaling pathway plays pivotal roles in regulating tumor angiogenesis. Quantitative positron emission tomography (PET) imaging of VEGFR will facilitate the planning of whether, and when, to start anti-angiogenic treatment and enable more robust and effective monitoring of such treatment," scientists writing in the journal Molecular Imaging and Biology report. "VEGF(121) was conjugated with DOTA (1,4,7,10-tetra-azacylododecane N,N',N'',N'''-tetraacetic acid) and then labeled with Cu-64 for PET imaging of mice bearing different-sized human glioblastoma U87MG tumors (n=15). Western blotting and...
Source: Cancer Weekly (2009-03-24)
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