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Antisense Technology
Scientists at Yale University target antisense technology
March 24th, 2009
"Genetic instability is a hallmark of cancer; the hypoxic tumor microenvironment has been implicated as a cause of this phenomenon. MicroRNAs (mill) are small nonprotein coding RNAs that can regulate various cellular pathways," scientists in the United States report. "We report here that two mills, miR-210 and miR-373, are up-regulated in a hypoxia-inducible factor-la-dependent manner in hypoxic cells. Bioinformatics analyses suggested that these mills could regulate factors implicated in DNA repair pathways. Forced expression of miR-210 was found to suppress the levels of RAD52, which is a key factor in homology-dependent repair (HDR); the forced expression of miR-373...
Source: Cancer Weekly (2009-03-24)
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