Cancer Weekly
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Apoptosis
Findings from University of California in apoptosis reported
March 24th, 2009
"Transforming growth factor beta (TGF beta), is a paracrine mediator of prostate epithelial cell apoptosis. In rodents, castration induces production of TGF beta by stromal cells, which leads to apoptosis of epithelial cells," scientists in the United States report. "To identify potential mediators of this cell death pathway, we developed a model using DU145 cells, a tumorigenic human prostate epithelial cell line. We discovered that at low density. in low mitogen media, DU145 cells apoptose when treated with TGF beta 1. Prior to the onset of death, TGF beta 1 treatment down-regulated the expression of the caspase inhibitor FLICE-like inhibitory protein (FLIP), at both...
Source: Cancer Weekly (2009-03-24)
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