Squamous Cell Carcinoma

New squamous cell carcinoma data have been reported by M. Moral and co-authors

Published in Cancer Weekly, March 24th, 2009

"Head and neck squamous cell carcinoma (HNSCC) is a common human neoplasia with poor prognosis and survival that frequently displays Akt overactivation. Here we show that mice displaying constitutive Akt activity (myrAkt) in combination with Trp53 loss in stratified epithelia develop oral cavity tumors that phenocopy human HNSCC," scientists writing in the journal Cancer Research report.

"The myrAkt mice develop oral lesions, making it a possible model of human oral dysplasia. The malignant conversion of these lesions, which is hampered due to the induction of premature senescence, is achieved by the subsequent ablation of Trp53 gene in the same cells in vivo....

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Source: Cancer Weekly (2009-03-24)

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