Tissue Engineering
Investigators at Beatson Institute for Cancer Research target tissue engineering
Published in Cancer Weekly, March 24th, 2009
Current study results from the report, 'Regulation of human myoblast differentiation by PEBP4,' have been published. "The RAF-MEK-ERK pathway regulates both myoblast proliferation and differentiation; however, it is unclear how these events are coordinated. Here, we show that human phosphatidylethanolamine-binding protein 4 (PEBP4), a RAF kinase inhibitory protein (RKIP) family protein expressed preferentially in muscle, regulates the activity of the ERK pathway and myoblast differentiation by acting as a scaffold protein," scientists writing in the journal Embo Reports report.
"In contrast to RKIP, which disrupts the RAF1-MEK interaction, PEBP4 forms ternary...
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Source: Cancer Weekly (2009-03-24)
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