Cancer Weekly
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Stomatitis
New data from J. Altomonte et al illuminate research in stomatitis
March 31st, 2009
"Recombinant oncolytic viruses represent a promising alternative option for the treatment of malignant cancers. We have reported earlier the safety and efficacy of recombinant vesicular stomatitis virus (VSV) vectors in a rat model of hepatocellular carcinoma (HCC)," scientists writing in the journal Cancer Gene Therapy report. "However, the full potential of VSV therapy is limited by a sudden decline in intratumoral virus replication observed early after viral administration, a phenomenon that coincides with an accumulation of inflammatory cells within infected lesions. To overcome the antiviral function of these cells, we present a recombinant virus,...
Source: Cancer Weekly (2009-03-31)
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