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Cancer Gene Therapy
Reports from University of Pais Vasco advance knowledge in cancer gene therapy
March 31st, 2009
Research findings, 'Identification of (1H)-pyrroles as histone deacetylase inhibitors with antitumoral activity,' are discussed in a new report. "Histone deacetylases (HDACs) play a key role in the regulation of gene expression and chromatin structure, and drugs targeting these enzymes might have an important impact in the treatment of human cancer. Herein, we report the characterization of (1H)-pyrroles as a new subfamily of HDAC inhibitors obtained by computational modeling of class-I human HDACs," scientists in Spain report. "From a functional standpoint, (1H)-pyrroles are powerful inductors of acetylation of histones H3 and H4, and restore the expression of...
Source: Cancer Weekly (2009-03-31)
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