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Cancer Gene Therapy
Researchers from University of Kentucky report on findings in cancer gene therapy
March 31st, 2009
Researchers detail in 'PDGF-A promoter and enhancer elements provide efficient and selective antineoplastic gene therapy in multiple cancer types,' new data in cancer gene therapy. "Development of antineoplastic gene therapies is impaired by a paucity of transcription control elements with efficient, cancer cell-specific activity. We investigated the utility of promoter (AChP) and 5'-distal enhancer (ACE66) elements from the platelet-derived growth factor-A (PDGF-A) gene, which are hyperactive in many human cancers," scientists in the United States report. "Efficacy of these elements was tested in multiple tumor cell lines, both in cell culture and as tumor explants in...
Source: Cancer Weekly (2009-03-31)
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