Cancer Weekly
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Acute Myeloid Leukemia
Reports summarize acute myeloid leukemia research from R.T. Calado and co-authors
March 31st, 2009
"Loss-of-function mutations in telomerase complex genes can cause bone marrow failure, dyskeratosis congenita, and acquired aplastic anemia, both diseases that predispose to acute myeloid leukemia. Loss of telomerase function produces short telomeres, potentially resulting in chromosome recombination, end-to-end fusion, and recognition as damaged DNA," researchers in the United States report. "We investigated whether mutations in telomerase genes also occur in acute myeloid leukemia. We screened bone marrow samples from 133 consecutive patients with acute myeloid leukemia and 198 controls for variations in TERT and TERC genes. An additional 89 patients from a second...
Source: Cancer Weekly (2009-03-31)
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