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Cancer Weekly

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Angiogenesis



Researchers from Okayama University report recent findings in angiogenesis



March 31st, 2009

"Soluble factors in the tumor microenvironment may influence the process of angiogenesis; a process essential for the growth and progression of malignant tumors. In this study, we describe a novel antiangiogenic effect of conditional replication-selective adenovirus through the stimulation of host immune reaction," researchers in Okayama, Japan report.

"An attenuated adenovirus (OBP-301, Telomelysin), in which the human telomerase reverse transcriptase promoter element drives expression of El genes, could replicate in and cause selective lysis of cancer cells. Mixed lymphocyte-tumor cell culture demonstrated that OBP-301-infected cancer cells stimulated PBMC to produce...


Source: Cancer Weekly (2009-03-31)

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