Cancer Gene Therapy

Investigators at Sichuan University zero in on cancer gene therapy

Published in Cancer Weekly, March 31st, 2009

"Angiogenesis plays an important role in the growth of solid tumors. To date, no information has been acquired on the effectiveness of gene therapy in the orthotopic lung cancer model of syngeneic immunocompetent mice treated with an angiogenesis inhibitor," scientists in Chengdu, People's Republic of China report.

"Here, we report the establishment of such a model in which Lewis lung carcinoma (LL/2) cell suspensions were orthotopically inoculated into the lung parenchyma of C57BL/6 mice, which were also injected with a recombinant adenoviral vector delivering the human endostatin gene (Ad-hE). We found that orthotopic implantation of LL/2 cells into the lung...

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Source: Cancer Weekly (2009-03-31)

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