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Cancer Gene Therapy
Studies from F. Mori et al in the area of cancer gene therapy described
March 31st, 2009
"A genetic vaccine platform based on DNA electroporation (DNA-EP) and adenovirus ( Ad) was used to generate immune response against human carcinoembryonic antigen (CEA) and antitumor effects in murine models with spontaneous tumors arising in an orthotopic location. CEA transgenic ( CEA," scientists in Pomezia, Italy report. "Tg) mice treated with the carcinogen 1,2-dimethylhydrazine developed CEA-overexpressing tumors that resembled human sporadic colorectal cancer. APC1638N/CEA hybrid mice, generated by crossing mice carrying the adenomatous polyposis coli (Apc1638N) gene mutation with CEA. Tg mice, are representative of human familial polyposis and develop polyps...
Source: Cancer Weekly (2009-03-31)
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