Cancer Gene Therapy

Studies from F. Mori et al in the area of cancer gene therapy described

Published in Cancer Weekly, March 31st, 2009

"A genetic vaccine platform based on DNA electroporation (DNA-EP) and adenovirus ( Ad) was used to generate immune response against human carcinoembryonic antigen (CEA) and antitumor effects in murine models with spontaneous tumors arising in an orthotopic location. CEA transgenic ( CEA," scientists in Pomezia, Italy report.

"Tg) mice treated with the carcinogen 1,2-dimethylhydrazine developed CEA-overexpressing tumors that resembled human sporadic colorectal cancer. APC1638N/CEA hybrid mice, generated by crossing mice carrying the adenomatous polyposis coli (Apc1638N) gene mutation with CEA. Tg mice, are representative of human familial polyposis and develop polyps...

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Source: Cancer Weekly (2009-03-31)

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